Chin-San Liu Selected Research

polyglutamine

8/2022	Coenzyme Q10 Supplementation Increases Removal of the ATXN3 Polyglutamine Repeat, Reducing Cerebellar Degeneration and Improving Motor Dysfunction in Murine Spinocerebellar Ataxia Type 3.
7/2022	In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3.
2/2019	Far-infrared Radiation Improves Motor Dysfunction and Neuropathology in Spinocerebellar Ataxia Type 3 Mice.
1/2018	Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
1/2017	Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3.
1/2016	Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function.
6/2009	Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
1/2008	Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases.

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Chin-San Liu Research Topics

Disease

14	Neoplasms (Cancer) 09/2022 - 11/2008
12	Mitochondrial Diseases (Mitochondrial Disease) 03/2024 - 05/2005
11	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2023 - 01/2003
6	Stroke (Strokes) 11/2022 - 05/2005
6	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2022 - 01/2008
6	Atherosclerosis 02/2020 - 11/2004
6	Myocardial Infarction 11/2017 - 01/2013
5	Parkinson Disease (Parkinson's Disease) 03/2024 - 09/2007
5	Breast Neoplasms (Breast Cancer) 09/2022 - 09/2010
5	MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers) 12/2013 - 05/2005
4	Cardiovascular Diseases (Cardiovascular Disease) 11/2022 - 11/2004
4	Ischemic Stroke 11/2022 - 05/2006
4	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2019 - 12/2012
4	Inflammation (Inflammations) 11/2017 - 04/2012
4	MELAS Syndrome (Syndrome, MELAS) 01/2017 - 05/2005
3	Neuroblastoma 07/2022 - 01/2016
3	Osteosarcoma (Osteogenic Sarcoma) 01/2022 - 06/2016
3	Pelvic Organ Prolapse 07/2019 - 07/2009
3	Hypertension (High Blood Pressure) 01/2018 - 01/2011
3	ST Elevation Myocardial Infarction 08/2016 - 01/2013
3	Hypercholesterolemia 01/2016 - 02/2010
3	Infections 10/2015 - 07/2008
3	Lung Neoplasms (Lung Cancer) 12/2014 - 03/2009
2	Parkinsonian Disorders (Parkinsonism) 03/2024 - 01/2021
2	Dyslipidemias (Dyslipidemia) 11/2022 - 01/2016
2	Triple Negative Breast Neoplasms 09/2022 - 01/2020
2	Carotid Stenosis (Carotid Artery Stenosis) 02/2020 - 01/2018
2	Diabetic Nephropathies (Diabetic Nephropathy) 12/2018 - 10/2015
2	Hearing Loss (Hearing Impairment) 10/2018 - 12/2012
2	Necrosis 11/2017 - 01/2016
2	Ovarian Neoplasms (Ovarian Cancer) 06/2017 - 05/2014
2	Aneurysm (Aneurysms) 09/2015 - 01/2015
2	Intracranial Aneurysm (Cerebral Aneurysm) 09/2015 - 01/2015
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2015 - 11/2008
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2015 - 11/2008
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2015 - 03/2007
2	Rupture 01/2015 - 06/2010
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 08/2014 - 01/2013
2	Ataxia (Dyssynergia) 12/2012 - 12/2010
2	Spinocerebellar Degenerations (Marinesco Sjogren Syndrome) 12/2012 - 12/2010
2	Epilepsy (Aura) 09/2007 - 01/2002
1	Retinal Degeneration 11/2022
1	Weight Loss (Weight Reduction) 08/2022
1	Muscular Atrophy (Muscle Atrophy) 08/2022
1	Atrophy 07/2021
1	Alopecia (Baldness) 10/2020
1	Cerebral Infarction 02/2020

Drug/Important Bio-Agent (IBA)

35	Mitochondrial DNA (mtDNA)IBA 07/2019 - 05/2005
15	Biomarkers (Surrogate Marker)IBA 02/2020 - 12/2010
11	Proteins (Proteins, Gene)FDA Link 03/2024 - 03/2007
9	Cyclophilin AIBA 02/2020 - 12/2013
8	polyglutamineIBA 08/2022 - 01/2008
7	Peptides (Polypeptides)IBA 01/2017 - 01/2013
6	Ataxin-3IBA 07/2022 - 01/2003
6	DNA (Deoxyribonucleic Acid)IBA 10/2019 - 11/2008
5	AntioxidantsIBA 08/2022 - 01/2002
5	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2017 - 05/2010
4	Interleukin-6 (Interleukin 6)IBA 11/2022 - 04/2012
4	Cell-Penetrating PeptidesIBA 01/2019 - 01/2013
4	beta Carotene (Betacarotene)FDA Link 12/2014 - 11/2008
4	alpha-Tocopherol FDA Link 12/2014 - 11/2008
4	oxidized low density lipoproteinIBA 01/2013 - 05/2005
3	coenzyme Q10 (CoQ10)IBA 08/2022 - 09/2007
3	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2022 - 06/2016
3	ResveratrolIBA 01/2018 - 01/2015
3	InterleukinsIBA 11/2017 - 04/2012
3	CytokinesIBA 01/2017 - 12/2013
3	Anticonvulsants (Antiepileptic Drugs)IBA 08/2014 - 01/2002
3	EnzymesIBA 01/2014 - 03/2007
3	Indicators and Reagents (Reagents)IBA 12/2010 - 01/2008
2	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 03/2024 - 01/2021
2	Ethanol (Ethyl Alcohol)IBA 01/2023 - 01/2019
2	Growth Hormone (Somatotropin)IBA 02/2022 - 07/2021
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 06/2016
2	Glutamine (L-Glutamine)FDA Link 10/2019 - 01/2008
2	caffeic acidIBA 01/2018 - 01/2017
2	Matrix Metalloproteinases (MMPs)IBA 02/2016 - 12/2013
2	Atorvastatin (Lipitor)FDA Link 01/2016 - 02/2010
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2016 - 01/2008
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2016 - 02/2010
2	ORALIT (ORS)IBA 12/2014 - 05/2010
2	AutoantibodiesIBA 01/2013 - 12/2010
2	HomocysteineIBA 01/2008 - 11/2004
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2008 - 11/2004
1	Therapeutic UsesIBA 03/2024
1	Formoterol Fumarate (Oxis)FDA Link 03/2024
1	erinacine AIBA 01/2023
1	Proprotein Convertase 9IBA 11/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2022
1	NF-kappa B (NF-kB)IBA 09/2022
1	3- (2,4- dichloro- 5- methoxyphenyl)- 2- sulfanyl- 4(3H)- quinazolinoneIBA 09/2022
1	Muscle Proteins (Muscle Protein)IBA 08/2022
1	omaveloxoloneIBA 07/2022
1	Dimethyl FumarateIBA 07/2022
1	CurcuminIBA 07/2022
1	Insulin-Like Growth Factor I (IGF-1)IBA 02/2022
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2021

Therapy/Procedure

12	Therapeutics 09/2022 - 01/2002
7	Transplantation 11/2022 - 10/2015
1	Secondary Prevention 11/2022